Word: patients
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...business interests have actually been a factor in curbing innovations, the GAO found. During the past decade the pharmaceutical industry has tended to focus on "blockbuster drugs" for large patient populations that can generate as much as $1 billion in annual sales, while ignoring "other drugs for more limited populations that generate much less revenue." Manufacturers find "me too" drug development less risky and more potentially lucrative than research into brand-new medications. Drug company mergers in the early 1990s also have resulted in the larger firms' scaling back R&D into new drugs as they look to cut costs...
...National Academy of Sciences convene a panel of 14 doctors, scientists, pharmaceutical industry researchers and patient advocates to come up with ways to spur innovation. They recommended more collaboration among government, industry and academia. Colleges, for example, could offer more scholarships to train translational researchers. The government could offer more incentives for innovative drug research. Patents for breakthrough drugs could be extended from the current 20 years to 25-30 years, while patents for "me too" drugs could be shortened to 10 years. Otherwise the billions for research will end up producing bigger profits, but not necessarily better medications...
...more than 24 consecutive hours a month are three times more likely to commit at least one significant fatigue-related error, and those who work more than five such shifts are seven times more likely to commit errors. The number of mistakes that result in the death of a patient jump 300 percent among residents who work more than five of the marathon shifts per month. Czeisler characterized most of the fatigue related mistakes as “slips and lapses,” which include giving a miscalculated dose, ordering a medication a patient is allergic to, and trying...
...play to our sentiments, he just lets them naturally evolve--even the animation of a few of her drawings doesn't feel especially forced. The result is an honorable and curiously winning film. BREAKING AND ENTERING Anthony Minghella's basic filmmaking impulse is toward the romantic epic (The English Patient, Cold Mountain). He likes to do long, ultimately unhappy love stories set against agitated historical backgrounds that impinge on the fates of his lovers. Breaking and Entering, though set in contemporary London, is a film of that character...
...body was shriveling, his bone marrow was failing, just as if he had been one of the firemen called to the burning reactor at Chernobyl. But gamma spectrometers found nothing unusual in his blood or urine. As doctors ruled out a slew of increasingly obscure toxins and bugs, the patient's condition worsened. In desperation, the police sent his urine to Britain's Atomic Weapons Establishment, which has equipment beyond the reach of any hospital. There, experts discovered Litvinenko's urine was teeming with radiation--not the gamma rays they had been looking for, which are the usual culprits...