Word: patients
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...important trigger for this turnaround, surprisingly enough, was vaccine research's most notable failure. In the 1980s, as the AIDS epidemic began to spread, scientists tried to fight it as they had polio and chickenpox--by crippling the virus and using it to train a patient's immune system to ward off the real infection. Nobody really understood how the process worked at the molecular level, but until AIDS came along, that didn't matter much...
...patient-ready AIDS vaccine may not be available for human trials for another decade, but once it is, Nabel and others plan to use every trick they have learned to boost its effectiveness. They may, for example, mix cytokines with the vaccine, counting on these chemicals to rally extra killer T cells against the virus. They may give a small jolt of electricity along with the priming dose of viral DNA; that shock seems to enhance the DNA's ability to trigger a response. And they are even experimenting with firing the DNA directly into immune-system cells at high...
Researchers are heartened by their preliminary success with a more complicated regimen, in which inoculations are custom-made from--and for--each patient. Early in 2001, scientists from Stanford University reported some shrinkage of advanced colon or lung tumors in half of a dozen patients. The vaccines they used were made of dendritic cells harvested from the patients themselves and mixed with a protein found on colon and lung tumors. These were then put back into the patients. "Our hope is to make these vaccines more potent and to try them in earlier-stage disease, possibly even using them...
...shutting down terrorism, in fact, Musharraf potentially strengthens Pakistan's diplomatic position in calling for an internationally mediated political solution that would allow Kashmir's own people to determine its fate - a prospect not relished in New Delhi. But the logic of Musharraf's crackdown, and India's patient response, suggests the potential for the emergence of a consensus between India and Pakistan that the fate of Kashmir should not be allowed to continue to disfigure their relationship, and their long-term national interests...
...year-old patient named Dov spent the war in Bergen-Belsen and came to Shaar Menashe after 40 years of treatment for depression in a private hospital, where he was given as many as 30 pills a day. "They used to take all my energy with their medicines," he says. "Why did they give me all those drugs?" Heath Minister Dahan said last week that he'd been to Shaar Menashe, apologizing to the survivors "in the name of the state of Israel and the Jewish people...