Word: pattersons
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...have unintended consequences. Vets believe the retinal disease that afflicts most collies may fall into this category. The gene responsible may lie very close to the one that gives collies their long noses and closely set eyes -- traits that have been deliberately emphasized by breeders. Says Dr. Donald Patterson, chief of the medical genetics section at the University of Pennsylvania's School of Veterinary Medicine: "Many people have bred dogs for desired traits, but in the process of doing this they have also got undesirable ones. The objective should be to combine breeding for good traits with more careful planning...
...laws are not entirely fair to breeders, though, says George Padgett, a veterinary pathologist at Michigan State University. "Some may be penalized unfairly because no one has taught them about genetic defects." Agrees Penn's Dr. Donald Patterson, founder of the genetic section of the University of Pennsylvania's School of Veterinary Medicine and widely acknowledged as the dean of canine genetic research, "The common misconception is that breeders are cavalier." The real problem, he says, is that they have not had the scientific information to detect hidden defects and thus avoid bad breeding decisions...
That is starting to change. One new tool that should prove helpful is a computerized genetic-disease data base developed at Patterson's lab that lists more than 300 genetic problems plaguing dogs. Another is the university's PennHIP program, a hip-disease-detection system that took 11 years and $1 million to develop. It involves taking detailed measurements of hip X rays to grade the severity of dysplasia. The program is being marketed by International Canine Genetics Inc., a research company based in Malverne, Pa., which is already training vets to use it. "A tighter-fitting hip joint...
Lists and detection systems are not the same as cures, but Patterson points out that veterinary researchers are finally beginning to have some insight into the causes of these disorders. "Canine genetic diseases," he says, "are now being defined at the molecular level, and the mapping of the canine genome is at last under way." Scientists have located the genes that cause muscular dystrophy in golden retrievers, and "shaking pup" syndrome in Welsh springer spaniels. They're working on identifying the genes responsible for failure-to-thrive metabolic problems in giant Schnauzers, bleeding disorders in Scottish terriers and Doberman pinschers...
Eight different Tigers have intercepted one pass apiece: Mark Berkowitz, Dave Patterson, Ryan Moore, Jonathan Reid, Damani Leech, Rich Hill, Tom Ludwig and Tom McInerney. SPORTS CUBE PREDICTS Darren M. Kilfara, Assoc. Sports Editor Princeton 32 Harvard 17 Michael E. Cineberg, Sports Staffwriter Princeton 31 Harvard 20 Jee Matthews, Managing Editor Harvard 28 Princeton 20 Emmoline F. Hou, Design Editor Princeton 27 Harvard...