Word: pauls
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Dates: during 1990-1999
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State Police pilots James Mattaliano and Paul Perry and two AT&T technicians heading to repair some telephone equipment in Framing ham were killed in the crash...
...scientists are exploring an entire spectrum of what Dr. Steven Paul, vice president for central-nervous-system research at Eli Lilly, calls "Clozaril wannabes" that they hope will work as well without triggering agranulocytosis. One of the wannabes, risperidone (Risperdal), made by Belgium-based Janssen Pharmaceutica, entered the market in 1993, and four others are nearing approval by the fda, including Lilly's Zyprexa and Abbott Labs' Serlect. Meanwhile, further down the drug-development pipeline are a number of third-generation Clozaril cousins, some of which are specifically targeted at the little-known D3 and D4 receptors...
...curing schizophrenia with these new antipsychotics," says Paul. "But we can treat it better. What would happen if we designed a drug that was 10 times better than Clozaril?" Mount Sinai's Davis, on the other hand, thinks future schizophrenia drugs might well be based on altogether different chemical-messenger systems. "There is evidence that schizophrenics have abnormalities in two very common neurotransmitters, gaba [gamma-aminobutyric acid] and glutamate," he says. "None of the current drugs do anything for the most incapacitating symptom of schizophrenia, the cognitive deficits. Maybe it's time to get off the dopamine merry-go-round...
...PAUL Republican--Texas 14th After serving in the House from 1976 to '84, Paul returns to Capitol Hill. A nasty campaign saw his opponent Charles ("Lefty") Morris paint him as a racist and an extremist...
RICHARD DURBIN Democrat--Illinois The seven-term Representative easily triumphed over conservative Al Salvi to keep Paul Simon's seat in Democratic hands...