Word: pedale
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...just as there are two ways to stop a speeding car--by easing off the gas or hitting the brake pedal--there are two different possibilities for muting addiction. If dopamine receptors are the gas, the brain's own inhibitory systems act as the brakes. In addicts, this natural damping circuit, called GABA (gamma-aminobutyric acid), appears to be faulty. Without a proper chemical check on excitatory messages set off by drugs, the brain never appreciates that it's been satiated...
...support of the U.N., his so-called $100 laptop quickly found backing from, among others, Google, Red Hat, Advanced Micro Devices and Nortel. His team is still making prototypes, but a finished motherboard was delivered in April. A wind-up crank has been replaced by a new foot pedal to supply power in areas lacking electricity...
...this context, moderate Democrats who had been initially inclined to soft-pedal their support for gun control might find it in their interest to defend the principle more forcefully. "Conceivably, the Supreme Court in Parker could do for gun-control advocates what Roe v. Wade did for pro-life advocates," says Robert J. Spitzer, political scientist at SUNY Cortland and author of The Politics of Gun Control. "It could be a catalyzing event." Both Republican and Democratic presidential candidates would have to reassure the political center that they supported modest forms of gun control, but Democrats would be freer...
...estimates that there are about 35 million sewing hobbyists in the U.S., up from roughly 30 million in 2000, and annual sales of machines have doubled since 1999, to 3 million. Since the seamstresses in this new generation are less likely to have learned at their mother's foot pedal, they are looking for guidance. Stewart launched Blueprint magazine last year for them. The women's lifestyle magazine will publish six issues in 2007, up from two in 2006, and reaches a total audience of 250,000. While the flagship Martha Stewart Living magazine features sewing projects for the home...
...Loesser kept feeding her novelty numbers to test her skills of pronunciation and breath control. Often the songs have her complaining, if not about a boyfriend, then about work. "The Sewing Machine" (from The Perils of Pauline): "I bobbin the bobbin and pedal the pedal / And wheel the wheel all day/ So by night I feel so weary / That I never get out to play." And in another Pauline song, the sublimely frantic "Rumble Rumble Rumble," Betty practically falls off the piano top she's perched on, so agitated is she singing about how she can't get to sleep...