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...last week. In preliminary tests sponsored by Boehringer Ingelheim Pharmaceuticals, an experimental compound with an ungainly moniker--BIRR 4--managed to cut the severity of cold symptoms in half without major side effects. The results were immediately hailed in the media as a breakthrough, although Dr. Ronald Turner, a pediatrician at the Medical University of South Carolina in Charleston who helped direct the research, was quick to add a dose of caveat. "We've got a ways to go," he insists, "before we can say the word cure...

Author: /time Magazine | Title: FOOL A COLD | 10/13/1997 | See Source »

...Twelve disorders that I see here are founder-gene defects carried by the dozen families that established this population 300 years ago," observes Dr. D. Holmes Morton, 47, a pediatrician and geneticist who gave up an academic career to work among the Amish. One of those diseases, he has discovered, is glutaric aciduria, a metabolic deficiency that usually strikes children between the ages of 6 months and 5 years. Often triggered by childhood illnesses such as chickenpox or strep throat, it can cause permanent brain injury that can lead to chronic disability, medical complications and even early death...

Author: /time Magazine | Title: A DARK INHERITANCE | 10/1/1997 | See Source »

Over the years, Morton has traced each family's genetic heritage through 14 generations. He has determined a carrier frequency for the disorder among the Amish of about 1 in 10 people. Working with Dr. Richard Kelley, a pediatrician, Morton diagnosed glutaric aciduria in 16 other Amish children. The doctors' studies predicted that 50 more children born in the next generation would inherit the two copies of the defective gene needed to cause the disorder. According to the statistics, without treatment nearly all would be disabled, and 12 of them would die before age 5. "Glutaric aciduria is a treatable...

Author: /time Magazine | Title: A DARK INHERITANCE | 10/1/1997 | See Source »

This time he's Nicholas Van Orton, super-rich investment banker, too busy to pay attention to his ex-wife--"She married a pediatrician or a gynecologist, or a pediatric gynecologist"--and too stuffy to bond with his rakehell brother Conrad (Sean Penn). As a birthday present, Conrad gives Nick a card for CRS, Consumer Recreation Services, an outfit that devises elaborate, personalized games for select clients. And now Nick is the lucky--or doomed--fellow chosen to play. Nick...

Author: /time Magazine | Title: CINEMA: THESE JOKERS ARE WILD | 9/22/1997 | See Source »

...when you look a little closer at these findings, they start to seem a bit murky. To begin with, observes Dr. Den Trumbull, a Montgomery, Ala., pediatrician who is vocal in the spanking debate, the mothers ranged in age from 14 to 21. That is hardly a representative slice of American motherhood. Moreover, those who spanked did so on average twice a week. These factors, says Trumbull, plus the fact that some of the kids were as old as nine, "are markers of a dysfunctional family in my mind, and in the minds of most psychologists and pediatricians...

Author: /time Magazine | Title: SPARE THE ROD? MAYBE | 8/25/1997 | See Source »

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