Word: peg
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Dates: during 1990-1999
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...Ohio girls, ages 4 and 9. Neither child was producing ADA, an enzyme that rids the bloodstream of harmful metabolic products. The absence of ADA can cause SCID by allowing toxic substances to accumulate and destroy immune-system cells. Both children had been kept alive by weekly injections of PEG-ADA, a costly synthetic enzyme, but neither was in good health...
Although Richard and Lori Riggins, of Exeter, California, have a normal four-year-old daughter, a son born to them in 1991 was diagnosed with SCID at the age of four weeks, and ever since has required treatment with PEG-ADA to survive. His disorder was evidence that both his mother and father, while healthy themselves, carried a recessive gene for SCID. This meant that any of their offspring would have a 1-in-4 chance of being stricken with the disease. The outlook was equally gloomy for Crystal Emery and Leonard Gobea, from California's Imperial Valley; their first...
...guard against the possibility that the gene therapy will not work, doctors will initially treat both infants with weekly injections of PEG-ADA. "We have no intention of letting these children get sick while we're waiting to see if the stem cells ((become functional))," says Wara. "When we see that this has happened, then we will start withdrawing the enzyme replacement." But will it happen? "My personal hunch is that this is going to benefit these two children," says Kohn. "If it does, then we can go on to more common diseases...
...enough to insist on having a real job as First Lady. Nor was it enough to begin reinventing America's health-care system. This time Hillary Rodham Clinton has done something really radical: she has made it almost impossible for people to peg her with a permanent caricature. First came the Republican version of a sharp-elbowed, pointy-headed wife determined to play out her ambition through her husband's campaign for the White House; then came Hillary as a cross between Betty Crocker and Joan of Arc, a cathartic role model for women who need to believe that someone...
...core of Walter Becker, who played guitar and bass, and Donald Fagen, whose keyboards and reedy, world-weary vocals helped give Steely Dan its inimitable sound. The duo reached a stylistic apotheosis with the 1977 album Aja, a seamless amalgam of rock and jazz idioms that spawned the single Peg. Three years later, Becker and Fagen joined forces one last time for Gaucho, before, in Fagen's words, reaching "a dead...