Word: penicillins
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...trouble with the wonder drug penicillin is that it stays only a brief hour or so in the bloodstream, is then lost, chiefly in the urine. Two ways of making the precious drug do double-duty were announced last week...
...About 30% of the penicillin can be recovered from urine by a simple extraction process. Dr. Lawrence Henry Sophian, of the U.S. Marine Hospital on New York's Staten Island, now uses reclaimed penicillin for gonorrhea patients, tells how he reclaims it in the Journal of Laboratory and Clinical Medicine...
...prolong penicillin's stay in the blood, Army Captain Monroe James Romansky and Technician (4th Grade) George E. Rittman suspend the drug in a mixture of beeswax and peanut oil and inject it into a muscle. They find that the suspension maintains a good level in the blood for six or seven hours after injection and keeps appearing in the urine up to 32 hours. The drug is extracted from the urine with banana oil, from the banana oil with a special phosphate solution...
...discovery was made accidentally, in almost the same way as Dr. Alexander Fleming's finding of penicillin. The Buffalo researchers noticed a green fungus growing on a culture of tubercle bacilli stored in an icebox. The mold seemed to have an affinity for the tubercle germ; it did not grow well in any other medium. It produced a substance (not penicillin, which has been ineffective against tuberculosis) that checked the growth of tubercle bacilli. A preparation from the mold neutralized tuberculin in two hours...
...Hilleboe has no dramatic new weapons for his offensive. Penicillin and most of the sulfa drugs have failed against the tubercle bacillus; the few drugs that do show promise (diasone, promizole, etc.) are still largely experimental...