Word: pentostam
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Dates: during 1997-1997
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...Donovan demonstrated that specimens could be extracted from the spleen. In their honor, the deadly parasite is called Leishmania donovani. Variants of kala-azar are found in southern Europe and South America. A complex treatment involving daily injections of a potentially toxic, antimony-based compound (as in the drug Pentostam) has been available for a half-century...
...late 1995, it looked as though the epidemic in southern Sudan was beginning to wane. Seaman and the MSF staff had treated about 19,000 patients, principally by administering daily injections of Pentostam. Keeping track of up to 1,400 patients at a time, most of whom were unable to read, required the creation of a massive card-filing system and the training of a competent local staff. Family members were taught to fill syringes to lines marked with tape and then to administer the doses themselves. "Jill Seaman has treated more cases of kala-azar than anyone else...
...immune system that any subsequent infection is often fatal. In August, McHarg dispatched Seaman to Ethiopia to survey a new outbreak of kala-azar. Seaman is also working on a pilot project to try out a drug for kala-azar that will cost a tenth the price of Pentostam...
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