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Ebright hopes myxopyronin will be especially useful in the battle against drug-resistant tuberculosis, a disease for which clinicians have never had a perfect therapy. The success of TB treatment depends on the destruction of active and dormant bacteria to prevent relapse - something that few existing antibiotics have been able to do. One way to kill a dormant cell is to target biochemical processes that continue even in latency - there aren't many of those. But myxopyronin works by interfering with the enzyme RNA polymerase, which controls gene transcription in cells and is necessary for cell survival, dormant...
...most inspiring. To be willing to risk everything in the pursuit of truth and protection of mankind is audacious, but also noble. Lina’s big heart and Doon’s obsession with the beauty and complexity of the generator and The Builders create the perfect dynamic to unveil this world-altering secret. And yet, it’s almost hard to believe that people would want to leave the fascinating place that is Ember City. Its inhabitants are not aware of Earth’s glorious miracles like sunsets, fall foliage, sunny days, and starry nights; what...
...skating was about going out your door and skating whatever’s in front of you, you could turn on 10 times more kids than having just a ramp,” Nichols says.The spirit of adventure that characterized the pioneers of street-skating found its perfect home in the new plazas that were being added on to building projects all across the city.“It is completely natural that skaters would move into these areas,” Kayden says. “They are public spaces, they have the various steps and ledges and railings...
...What's more, a new "Adverse Market Fee" recently instituted by lenders for borrowers with less than perfect credit (regardless of the market) could raise the cost of a loan another half a percentage point - or an additional $70 a month on that same $200,000 loan - for nearly 20% of Americans. "For individuals looking to buy a home this is going to be just one more obstacle in their way," says Barry Ziggus, who tracks housing issues for the Consumer Federation of America...
...debate, McCain returned to the acceptable boundaries of presidential politics with a punchy new stump speech that was plenty critical of Obama but critical on matters of substance, not inference. Obama would raise taxes. He would spend too much. He would "concede defeat in Iraq." And then, in a perfect valedictory to his career, McCain said, "I'm an American. And I choose to fight." It is impossible to say what McCain's fate would have been if he had taken this tough but traditional tack and also chosen Senator Joe Lieberman, the Vice President he really wanted, as former...