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...some interesting properties. For starters, says University of Frankfurt psychopharmacologist Walter Muller, it appears to affect the brain in the same way Prozac does--by prolonging the activity of the mood-enhancing brain chemical serotonin. This is the same neurotransmitter acted on by the controversial diet pills fen-phen and Redux (see following story). But hypericum has much broader activity. In rats and mice, at least, it extends the action of at least two other powerful brain chemicals that are thought to play a role in depression: dopamine and norepinephrine. In each case, hypericum appears to work not by stimulating...
Less than a year ago, a new generation of diet pills seemed to offer the long-sought answer to our chronic weight problems. Hundreds of thousands of pound-conscious Americans had discovered that a drug combination known as "fen-phen" could shut off voracious appetites like magic, and the FDA had just approved a new drug, Redux, that did the same with fewer side effects. Redux would attract hundreds of thousands of new pill poppers within a few months...
...facing a backlash. Some of the nation's largest HMOs, including Aetna U.S. Healthcare and Prudential Healthcare, have begun cutting back or eliminating reimbursement for both pills. Diet chains like Jenny Craig and Nutri/System are backing away from them too. Several states, meanwhile, have restricted the use of fen-phen. Last week the Florida legislature banned new prescriptions entirely and called on doctors to wean current patients from the drug within 30 days; it also put a 90-day limit on Redux prescriptions. Even New Jersey doctor Sheldon Levine, who touted Redux last year on TV and in his book...
...reason for all the retrenchment: potentially lethal side effects. Over the summer, the FDA revealed that 82 patients had developed defects in their heart valves while on fen-phen, and that seven patients had come down with the same condition on Redux (which is a chemical cousin of fenfluramine, the "fen" in fen-phen...
...that weren't bad enough, physicians reported that a woman who had been taking fen-phen for less than a month died of primary pulmonary hypertension, a sometimes fatal lung condition already associated with Redux. And an article in the Journal of the American Medical Association last month confirmed earlier reports that both fen-phen and Redux can cause brain damage in lab animals...