Word: phenformin
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During the past two years, Wolfe has taken his cases directly to the top. In April 1977, he alerted HEW Secretary Joseph Califano to existing FDA records linking phenformin, a drug used by one-fifth of all diabetics taking oral medication, to bad reactions in 190 cases and 93 deaths. Califano responded by invoking the "imminent hazard" law, which had never before been used, and banned the substance. Only last month, following another letter from Wolfe, Califano issued a sweeping warning about the dangers of DES, a drug once given to pregnant women to help prevent miscarriages that has since...
...Weller and Linder emphasize that these sulfonylureas promote the release of insulin-at least in the early stages of treatment-and thus help to make fat. They recommend sulfonylureas for patients whose weight problems are not critical and for the few who are underweight. For the overweight, they prescribe phenformin (U.S. Vitamin Corp.'s DBI), which, they say, helps both to control appetite and to speed the metabolism of blood sugar...
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