Word: phenyl
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Dates: during 1930-1939
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Like dinitrophenol, Prontosil is an aro matic coal tar product. Prontosil's full chemical formula is the disodium salt of 4-sulph-amido-phenyl-2-azo-7-acetylamino-1-hydroxynaphthalene 3.6-disulfonic acid. All doctors fear new drugs derived from coal tar. They may exhibit unexpected deadliness. In the case of Prontosil, since like dinitrophenol it affects the production of white blood cells, it comes under the medical rule of thumb: what ever stimulates may also destroy. And it may be that the new drug by which Dr. Tobey cured Franklin Roosevelt Jr.'s septic sore throat...
...drug which most often causes granulopenia in the U. S. is amidopyrine (chemical name: dimethylamrno-phenyl dimethyl pyrazolone). Related drugs which Dr. Kracke also blames are: pyramidon, phenacetine, arsphenamine. neoarsphenamine, amytal compound, allonal, peralga, amidophen. Dinitrophenol causes the rapid oxidization of sugar and fat in the body. This year it killed at least two overeager fat-reducers (TIME, April 30). Dr. Kracke said he feared it would be exploited this winter as a weight reducer...