Word: phenylketo
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Dates: during 1956-1956
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Pauling's argument: molecular disease arises when defective genes cause the body to manufacture abnormal molecules. Up to i% of the 2,000,000 mental defectives in the U.S. suffer from phenylketo-nuria-a mental disease accompanied by the body's failure to oxidize an amino acid, phenylalanine, to tyrosine. Probable cause of the failure is a defective enzyme. The Pauling project: to find out the connection between the molecular and men tal defects, and also whether the other 99% or more of mental defectives owe their handicap to a similar molecular abnormality caused by a combination...
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