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Running nose. raging fever. Aching joints. Splitting headache. Are there any poor souls suffering from the flu this winter who haven't longed for a pill to make it all go away? Relief may be in sight. Researchers at Gilead Sciences, a pharmaceutical company in Foster City, California, reported last week in the Journal of the American Chemical Society that they have discovered a compound that can stop the influenza virus from spreading in animals. Tests on humans are set for later this year...
...neuraminidase cuts the newly formed copies free to invade other cells. By blocking this enzyme, the new compound, dubbed GS 4104, prevents the infection from spreading. Other drug companies have tried targeting neuraminidase, but so far only Gilead has come up with a formula that can be taken in pill form...
...types in five different species of lab animals, according to a report in the latest issue of the Journal of the American Chemical Society. GS 4104 contains the infection by preventing newly-formed viruses from leaving the host cell. But don't expect to be able to take a pill to get rid of the flu anytime soon. Human trials are planned for later this year, with results expected in two or three years at the earliest. Even if those trials are successful, the main use of an anti-flu pill will probably be preventative. Although you can be sick...
...that upbeat news coverage is playing havoc with a decade of AIDS education. Doctors complain about patients who think that because their viral load is undetectable, the virus must be gone from their bodies. Wrong. AIDS counselors talk about teens who think that science has discovered a morning-after pill to undo last night's unsafe doings. It hasn't. And everybody is concerned that a false message will go out that AIDS has been defeated. With that, they figure, will come a return to the '70s, the whole goatish and unbuckled funfest. The cycle of infection will go wild...
...telomere work, is looking for the genes that direct telomerase production, believing he might be able to manipulate them so that the spigot for the enzyme can be turned on and off at will. "I think we are going to see fundamental medicines for aging," Harley says. "With a pill, with cell therapy, I think we may be able to treat aging in very specific areas...