Word: pincus
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Dates: during 1960-1969
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Since the natural secretion of progesterone inhibits egg during part of the monthly cycle and during pregnancy searchers thought that steady doses of it might completely ovulation. A few years ago Dr. John Rock, clinical professor of Gynecology and Dr. Gregory Pincus of the Worcester for Experimental Biology tested the hypothesis. Ovulation sharply reduced but even with massive doses it continued per cent of the time. The problem attracted the interest of pharmaceutical houses, though, and these firms eventually the more effective synthetic compounds...
Rebound Effect. Emphasis on the contraceptive powers of the progestins (as chemists call the semisynthetic cousins of progesterone, the natural hormone) is an ironic accident. Ten years ago, Dr. Gregory Pincus, 57, the Einstein-maned research chief at Worcester Foundation for Experimental Biology, was studying problems of overfertility and underfertility, using laboratory animals. What he learned led him to turn to Boston's Dr. John Rock for help. Rock, then professor of gynecology at Harvard, gave progesterone to women who seemingly could not conceive. They took the pills for 20 days of each monthly cycle. The hormone suppressed ovulation...
Natural progesterone is too costly and must be given in such massive doses as to be unsuited for wide use. Then Pincus and colleagues found that norethynodrel worked better and in far smaller doses. Pincus and Rock teamed with Puerto Rico's Dr. Edris Rice-Wray in a big-scale test of the drug as a contraceptive among San Juan slum dwellers. While "on the pills" only 16 out of 838 women in four study areas became pregnant and all 16 had skipped their pills occasionally. Equally important, among the 174 women who dropped out of the test because...
Looking at the cold statistics in the record books, U.S. Olympic Track Team Chairman Pincus Sober said: "We will face an uphill struggle to amass as many gold medals as we did in Helsinki (14) in 1952 or at Melbourne...
Some Congressmen, reported Newsmen Walter Pincus and Don Oberdorfer, took wives along on business trips and in many cases absorbed the extra costs as legitimate expenses, while others apparently used flimsy excuses for making official trips, frequently paid for personal purchases out of their expense money, and did not always make proper reimbursements. Items...