Word: pincus
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Since the natural secretion of progesterone inhibits egg during part of the monthly cycle and during pregnancy searchers thought that steady doses of it might completely ovulation. A few years ago Dr. John Rock, clinical professor of Gynecology and Dr. Gregory Pincus of the Worcester for Experimental Biology tested the hypothesis. Ovulation sharply reduced but even with massive doses it continued per cent of the time. The problem attracted the interest of pharmaceutical houses, though, and these firms eventually the more effective synthetic compounds...
...Rock and Pincus report "practically 100 per cent contraception" on the basis of four field trials involving 1200 in Puerto Rico and Haiti. Other investigators were at first what less successful, but with improved techniques, achieved perfect reliability. At present, for optimal results, the must be taken once a day, starting on the day after the menstruation and continuing for 20 days. A menstrual-like gins a few days after the last pill is taken. Five days later the should be resumed. Ironically, when one stops taking the greater than normal fertility sometimes results. Thus, the may enable sub-fertile...
...Pincus-Rock study 18 per cent of the women comp of unpleasant side effects. Since the symptoms almost always appeared when the patient became accustomed to the pills, believed that most of the problems were psychological. reactions were not at all consistent. About 30 per cent of the reported a decline in Libido, but about the same number increase. Some gained weight and some lost. But, regardless complaints, 39 per cent of the women felt that their general had improved; only 10 per cent felt worse...
Rebound Effect. Emphasis on the contraceptive powers of the progestins (as chemists call the semisynthetic cousins of progesterone, the natural hormone) is an ironic accident. Ten years ago, Dr. Gregory Pincus, 57, the Einstein-maned research chief at Worcester Foundation for Experimental Biology, was studying problems of overfertility and underfertility, using laboratory animals. What he learned led him to turn to Boston's Dr. John Rock for help. Rock, then professor of gynecology at Harvard, gave progesterone to women who seemingly could not conceive. They took the pills for 20 days of each monthly cycle. The hormone suppressed ovulation...
Natural progesterone is too costly and must be given in such massive doses as to be unsuited for wide use. Then Pincus and colleagues found that norethynodrel worked better and in far smaller doses. Pincus and Rock teamed with Puerto Rico's Dr. Edris Rice-Wray in a big-scale test of the drug as a contraceptive among San Juan slum dwellers. While "on the pills" only 16 out of 838 women in four study areas became pregnant and all 16 had skipped their pills occasionally. Equally important, among the 174 women who dropped out of the test because...