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...authors of the new paper, a team of 11 researchers led by University of Pittsburgh professor of epidemiology Stephen Wisniewski, were curious how the STAR*D group would compare with a typical group of patients selected for a run-of-the-mill drug-company trial for a new antidepressant - the very trials on which the Food and Drug Administration bases its decisions regarding new drug approval. Drawing on their own experiences in helping to conduct such trials, which have far more stringent inclusion criteria than the STAR*D group, Wisniewski and his team divided the STAR*D patients into...

Author: /time Magazine | Title: Why Antidepressants Don't Live Up to the Hype | 5/6/2009 | See Source »

Such findings help explain why antidepressants haven't quite lived up to their promise. But the University of Pittsburgh's Wisniewski, the lead author of the new study, cautions against interpreting the results as an indictment against greedy drug companies eager to exclude difficult patients in order to show better results. "If the population in a [clinical] trial were more representative, that would come at a cost," he says. Researchers expect a certain number of bad reactions during clinical trials; some of these reactions can cause serious medical problems. If patients enter a trial with multiple complications - if they...

Author: /time Magazine | Title: Why Antidepressants Don't Live Up to the Hype | 5/6/2009 | See Source »

Hoping to attend medical school, the Pittsburgh, Pa. native studied neurobiology at the College, working to complete the pre-med curriculum. Outside of lab and lectures, Joo stayed involved in the medical community as a member of the Harvard Cancer Society, serving as a regular volunteer at Massachusetts General Hospital...

Author: By Ahmed N. Mabruk, CRIMSON STAFF WRITER | Title: Harvard Sophomore Dies Early Sunday Morning | 5/4/2009 | See Source »

...After narrowly losing Philadelphia's mayoral election 1967 to a Pittsburgh millionaire, Specter continued to work as Philadelphia's District Attorney for eight years, overseeing 250,000 cases. In 1969, he hired two rival gang leaders as consultants to address the city's rising violence and the following year charged two white policemen with aggravated assault and battery in the shooting death of a black man - moves that won both derision and praise...

Author: /time Magazine | Title: Arlen Specter: A Republican No More | 4/29/2009 | See Source »

...Just two weeks ago, Specter was at a fundraiser in Pittsburgh bemoaning his increasingly isolated status in the Republican caucus on Capitol Hill. "He was commenting, There are only three of us left, only three Republican moderates left," said Clifford Levine, a Democrat who coordinated President Obama's campaign in western Pennsylvania and who also happens to be an active Specter supporter. "They're all retired, forced out, and the Republican Party was in effect cannibalizing itself...

Author: /time Magazine | Title: Pennsylvania Democrats Reserved on Specter | 4/29/2009 | See Source »

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