Word: plasminogen
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...found the protein was a small part of the plasminogen molecule," Lane said...
...team, which included Medical School Professor of Anatomy and Cellular Biology Dr. Judah M. Folkman, found that a fragment of the protein plasminogen prevents the growth of blood vessels around secondary tumors called metastases...
...Should plasminogen prove to be effective in clinical trials, the non-toxic protein would augment existing cancer treatments. "Most people discover they have tumors before they come into the doctor's office," Bouck said. "My highest hope has been that surgeons could remove the tumor and prevent tumors that are hidden," she said...
...heart drug hit the market in 1987 in a blinding flash of pitchmen, promotion and public relations hoo-ha. The product of biotech breakthroughs, TPA was touted as clearly superior to the competition, a clot-busting drug called streptokinase, on the market for 15 years. Though TPA (for tissue plasminogen activator) is 10 times as expensive as the older drug, the majority of U.S. doctors bought the pitch, and the new drug became the favored method of breaking up clots in heart-attack victims. Then last week an international team of researchers reported what some doctors had suspected all along...
...hospital study, sponsored by the National Institutes of Health and known as TIMI II (for thrombolysis in myocardial infarction phase II trial), involved 3,262 patients who had suffered apparent heart attacks. Within four hours of their attacks, all patients received a powerful clot dissolver, known as TPA (tissue plasminogen activator), along with heparin and aspirin to inhibit blood coagulation. Of the 1,636 patients in the invasive-strategy group, 928 underwent angiography and angioplasty within 18 to 48 hours after their attacks...