Word: plasmochin
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Dates: during 1940-1949
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...permanent cure for relapsing malaria (which plagues almost half the world's population). Its name: SN 13,276. Last week in Atlantic City, Squibb Institute's Dr. James A. Shannon released some promising facts about this newest member of the eight-aminoquinoline group (to which belongs Plasmochin, antimalarial drug developed by German scientists in 1926, later discarded as ineffective and too toxic...
...Plasmochin, another synthetic, does not kill asexual forms of the protozoa unless given in toxic doses, is therefore not used for eradicating symptoms. But in very small amounts it kills all sexual forms, is therefore used to supplement quinine or atabrine to prevent convalescents from passing protozoa on to mosquitoes. Plasmochin is safe to give simultaneously with quinine, but some doctors believe it produces toxic effects if given along with atabrine, advise waiting a few days after atabrine before giving...
...symptoms develop, start with quinine or totaquine, if possible, until fever goes down (about two or three days), follow with atabrine (about five days). After a two-day respite, give plasmochin...
Atabrine, however, is not a complete substitute for quinine since it attacks only one of the two forms of the malaria germ. Quinine attacks both. To make atabrine as effective as quinine it must be administered together with plasmochin (another synthetic). But the amount of plasmochin needed is small, and Winthrop has already increased its production...
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