Word: plough
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Dates: during 2000-2009
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After nearly two years of waiting, the results came out on Monday on the long-awaited heart drug Vytorin - and the news wasn't good. Vytorin's manufacturers, Merck and Schering-Plough, announced that while the drug reduced levels of LDL, or bad cholesterol, in a group of 750 patients, the medication, which has been on the market since 2004, had little effect on the buildup of plaque in the arteries, a harbinger of heart attack and stroke...
...extended delay in reporting the results of the Vytorin study - called ENHANCE - Schering-Plough spokesperson Lee Davies told TIME that it was due to the time involved in reading and interpreting the tens of thousands of images of the carotid arteries that the study generated - data that had been available since April 2006. The company's procrastination prompted much discussion among heart doctors and on Capitol Hill: At the end of 2007, the House Energy and Commerce Committee sent a letter to the two manufacturers asking for the findings - and noting that the end point of the study specified...
...even there, Vytorin failed to show much effect. Vytorin is actually the combination of two drugs - one of the early statin medications, simvastatin (also known as Zocor), made by Merck, and ezetimibe, or Zetia, made by Schering-Plough. Ezetimibe is the first cholesterol-lowering medication that works by blocking absorption of cholesterol in the gut, rather than regulating the fat's production in the liver, like other statins do. ENHANCE compared the effect of Vytorin to simvastatin alone, and showed little difference between the two medications when it came to plaque size in the arteries. Simvastatin came off patent...
...with Syria and in the north of the country where troops fought a bloody three-month battle against Islamist militants during the summer hashish growing season. Furthermore, the hashish farmers threatened to burn down the houses of local tractor owners who are hired each year by the government to plough up the illegal crops...
...Despite the economic surge, Kayseri and its region remain deeply conservative. There is only one bar in the city, and it is usually closed. Business leaders plough a portion of their profits back into schools, universities, hospitals and mosques - a form of tithing. Many women wear headscarves. Still, the recent prosperity is lending new texture to Turkey's traditional image as the meeting place of East and West. Celal Hasnalcaci, a local manufacturer of denim jeans for export, prays five times a day but adorns his office walls with photographs of young women striking provocative poses in low-cut jeans...