Word: podophyllin
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...cities (and 11,000 pages of testimony), the FTC issued a cease-and-desist order, only to have it tossed out by the U.S. Court of Appeals. After an appeal to the Supreme Court, which ordered further hearings, the FTC tried again in 1956. The pills, compounded chiefly of podophyllin (resin of dried root of the mayapple plant) and aloes (dried juice of the aloe plant), still do not stimulate liver bile, said...
Mandrake & Aloes. Dr. Carter sought his raw materials in nature. Podophyllum resin, or podophyllin, is the resin of the dried root of the mandrake or May apple; Carter combined this with the dried juice of aloes. He chose as his trademark an overstuffed black crow, which gave a nice zoological balance to Bull Durham's bull on the nation's barns. By 1880 the growing business was incorporated. Millions of pills were shipped all over the U.S. and abroad...
Manhattan's Memorial had podophyllin (an extract of mandrake root) on its research list; but through a laboratory accident some of the stuff prematurely got into test-tube cultures of cancerous and normal cells. It stopped the growth of the cancer cells, had no effect on the normal cells. Meanwhile, National Cancer Institute researchers tried podophyllin on mouse cancers, got comparable results...
...reported Drs. Richard Ormsbee and Ivor Cornman, podophyllin cannot be used on cancer patients until someone isolates its cancer-killing element and separates that from the rest. In any sizable quantity, the root is poisonous...
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