Word: polyoma
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...concept that IF might also be effective against cancer may have occurred spontaneously to several researchers after the work of Isaacs and Lindenmann was confirmed. After all, it had already been shown that some animal cancers were caused by the polyoma virus. Though no human cancer virus has yet been definitely identified, some tumors seem to be linked to viral infections. In recent years, for example, it has been shown that women with the genital disease caused by the herpes type II virus are more likely to develop cervical cancer than those who are free of that virus...
...first stage of the experiment, NIH'S Malcolm Martin and Wallace Rowe will splice DNA from the polyoma virus (which causes tumors in mice but not in humans) into a specially engineered strain of the common bacteria Escherichia coli. The bacteria will be fed to or injected into mice and hamsters, which will then be examined to determine 1) if the bacteria multiply into progeny that also contain the viral DNA, and 2) if the bacteria-carried viral DNA can cause tumors in the animals...
...Leon Goldman, a University of Cincinnati dermatologist, reports that doctors can say for certain only that warts are produced by a polyoma virus, a highly contagious carrier. According to Goldman's 20-year study, 60% of all warts are spread between family members; others are contracted in locker rooms, swimming pools and washrooms. He urges people with warts to cover them in order to prevent contagion. Neither Goldman nor his colleagues have found a satisfactory cure...
Thus some day, he speculates, man may be able to create artificial genes to replace missing ones in persons suffering from genetic diseases. The same technique could have other far-reaching effects. The polyoma virus, which produces a variety of cancers in many animals, is almost identical in size and complexity to Phi X 174. "If one can take the polyoma DNA and modify it in the test tube by implanting alternate genes," says Kornberg, "some of these could prevent the growth of cancer cells...
California virologists: Italian-born Dr. Renato Dulbecco, 50, now at the Salk Institute for Biological Studies in San Diego, and Dr. (of veterinary medicine) Harry Rubin, 38, of the University of California. Starting with viruses that infect bacteria, Dr. Dulbecco went on to show the mechanism by which polyoma virus, which causes many animal cancers, infects cells. Most important was the striking and unexpected finding that the virus itself, which has a nucleus of deoxyribonucleic acid (DNA), does not need to multiply in order to cause cancer...