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Duboule believes that over the eons of prehistory, Hox genes played a key role in the origin of species, facilitating the process of evolutionary change. Scientists now know, for example, that the genes that trigger the formation of hands and feet also control many other developmental processes in the posterior part of an animal -- among them, the addition of an anal opening to the digestive tract and, in four-legged creatures, the fusion of the lower vertebrae to make a pelvis. Isn't it curious, says Duboule, that fish lack a true pelvis as well as hands and feet? This...

Author: /time Magazine | Title: WHERE DO TOES COME FROM? | 7/31/1995 | See Source »

Scientists have long known that the posterior, or bottom, portion of the limb bud is important in signalling for developmental patterning. The group's work "demonstrated that the Sonic hedgehog gene encodes the key substance that makes the bottom of the limb bud so special," Tabin said...

Author: By Carrie L. Zinaman, | Title: Labs Play Video Game Biology | 1/12/1994 | See Source »

...difficult to figure out who's responsible for politics' vanilla flavor. Those self-important Cross Pen/paisley tie/hair gel gov jocks sucking your section leader's posterior become politicians when they grow up. And if you don't believe me, you didn't attend the IOP schmoozefest at Winthrop House last year, when undergraduates were introduced to the House of Representatives' newly elected members. As conversationalists, these Congressional airheads ranked slightly behind CPA's and slightly ahead of dead people...

Author: By Michael R. Grunwald, | Title: Are You Bored? I'm Bored. | 9/16/1991 | See Source »

...Hofher--the rookie coach with a Cornell Football jacket, Cornell Football shirt, Cornell Football hat, Cornell Football folder and no doubt a Cornell Football tattoo on his Cornell Football posterior--was talking about Cornell Football...

Author: By Michael R. Grunwald, | Title: It's Just a Game | 10/9/1990 | See Source »

...glint in his hazel eyes downright sexy. But it is also true that in preparing for Big, one scene of which displays all but a few centimeters of Hanks' pelt, he had to work out for weeks at a Manhattan gym, huffing and puffing to reduce that upholstered posterior, expand that narrow chest and flatten that soft stomach. Even so, he will not give Arnold Schwarzenegger any competition. In fact he found himself gasping at the end of a tough scene in which he and Robert Loggia dance a duet on giant piano keys embedded in the floor...

Author: /time Magazine | Title: Cinema: The Eternal Cutup at Work | 6/6/1988 | See Source »

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