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...prevents the formation of new blood vessels that feed tumors, reduces inflammation and kick starts the body's immune system. While existing anticancer agents kill off lymphocytes and white blood cells, which control immune and inflammatory responses, thalidomide has no toxic effect on them. It is also a potent inhibitor of cell movement, thus preventing inflammation around a tumor. Though thalidomide does have side effects, like dizziness and tingling in the toes, it is more gentle than existing therapies...

Author: /time Magazine | Title: Bad Drug Makes Good | 1/26/2003 | See Source »

...quest for a nuclear weapon has obsessed the Pyongyang regime since the 1950s, when Kim Il Sung began working to amass an arsenal potent enough to deter a feared U.S. attack. Though Pyongyang has made gestures suggesting it was ready to make concessions in exchange for aid and security guarantees, neither Kim Il Sung nor his son gave up the raw material for bombmaking or renounced the desire to obtain the Bomb; in their mind, doing so would sap the country's bargaining strength and make the regime's survival dependent on its neighbors' goodwill...

Author: /time Magazine | Title: How Dangerous Is North Korea? | 1/13/2003 | See Source »

Sell a buck. Save a buck. Repeat. It's that cycle of high-powered logistics engineering and nickel-squeezing huckstering that remains retailing's most potent weapon. UBS's Kristiansen sees no reason why Wal-Mart, which has trounced the Dow over the past five years, will not sustain 15% earnings growth...

Author: /time Magazine | Title: Can Wal-Mart Get Any Bigger? | 1/13/2003 | See Source »

Some actors who pick up the megaphone get an immediate Academy reward. Robert Redford (Ordinary People) and Kevin Costner (Dances with Wolves) won Best Director Oscars their first time out, and both triumphed in years when Martin Scorsese, widely acclaimed as the most potent picturemaker around, had strong contenders (Raging Bull and GoodFellas). This year Scorsese is likely to be nominated for Gangs of New York. Does he have nightmares of another first timer--Washington or Clooney--tiptoeing up Oscar's steps...

Author: /time Magazine | Title: What They Really Want is to Direct | 1/13/2003 | See Source »

...open one of the stacked cartons so shoppers could see they got both machines for one price. Soon a message went to all other stores: Open a box. Sales began to move immediately. That cycle of high-powered logistics engineering and penny-squeezing huckstering remains retailing's most potent weapon. UBS's Kristiansen sees no reason why Wal-Mart can't sustain earnings-per-share growth of 15%. Scott, who earns less than most other Fortune 500 CEOs, was leaving a store not long ago when he stopped to chat with one of the many senior citizens who work...

Author: /time Magazine | Title: Inside The World's Biggest Store | 1/12/2003 | See Source »

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