Word: presenilin
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Dates: during 1990-1999
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...research team reported in Thursday?s issue of the journal Nature that it had identified an enzyme, presenilin, that controls the production of a protein believed to be responsible for causing Alzheimer?s disease. Some 4 million Americans suffer from the debilitating memory loss. ?This is encouraging news for those afflicted with the devastating disease,? says TIME medical columnist Christine Gorman, ?but Alzheimer?s is still far from being conquered.? As with so many other medical discoveries, doctors and patients need to remain cautious. ?The report is significant from a research point of view,? says Gorman, ?but it needs...
...money to study things unless they think they have a good chance of developing a drug,? says Gorman. Thursday?s report gives encouragement that further study may eventually yield a payoff. But for now many questions still remain to be answered, not the least of which is this: If presenilin is indeed shown to be involved in causing Alzheimer?s disease, is it the only, the main or one of several causative factors...
Selkoe and his colleagues published their findings last month in the journal Nature Medicine, confirming that mutations in two genes previously known to be connected with early-onset familial A.D., presenilin one and two, do in fact stimulate production of a protein believed to be an important indicator of Alzheimer...