Word: progestins
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Dates: during 1960-1969
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...menopause to diabetes, arguing that both are deficiency diseases. His own efforts to correct woman's menopausal deficiency began in the 1920s. At first he had only crude hormone extracts, which had to be injected. Now there is a plethora of estrogens and of the other sex hormones, progestins and androgens. Most of them are at least partly synthetic, and they can be taken easily by mouth. A couple of years ago, a patient who had kept on taking the birth-control pill Enovid after her menopause gave Dr. Wilson a new insight: the pill-which contains both...
...adjusting the dosage until her femininity index is restored to 80% or better. For a woman with more severe symptoms, he prescribes estrogens plus a ten-day course of a synthetic progesterone substitute. A woman who is clearly past the menopause gets estrogen daily for six weeks plus a progestin tablet on each of the last ten days. The effect of this treatment is to restore a pseudomenstrual cycle of about seven weeks, with some bleeding in the last week. In no case do the hormones restore fertility...
...facts in the current case were simple and clear. Merck Sharp & Dohme was testing a pill containing two synthetic hormones. One is an estrogen, familiar and long in use; the second is a new progestin, closely related to those in pills already available but differing in detailed chemical structure. Although 340 women have taken the still-experimental pill for several months with no apparent ill effects, the manufacturer tried giving exceptionally large doses-20 to 40 times the human dose-to dogs. Two of the dogs in the experiment developed cancer...
...Plank's remarks followed a presentation by Dr. Gregory Pincus, who is known as the "father" of the pill, on the advantages of physiological control of conception. Dr. Plank, however, urged "continued cautious assessment" of the safety of the progestin-estrogen pills...
...five pink at the bottom. Working down the tube, a woman takes the first white pill (an estrogen) five days after beginning menstruation, and carries on with the white pills on a one-a-day schedule until they are finished. Then she takes the pink pills (a progestin) daily for five days. By thus imitating nature, say Mead Johnson and its medical investigators, the new pills provide almost 100% protection against conception, and they have almost no side effects...