Word: progestins
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...certainly not without consulting their doctors. Estrogen (with or without progestin) is still a perfectly reasonable medical treatment for many women with hot flashes or other symptoms of menopause. It can also help prevent or at least minimize osteoporosis...
...latest report on estrogen isn't bad news so much as it is incomplete news. Early data from a study involving 27,000 women, called the Women's Health Initiative, suggest that taking estrogen by itself or with the drug progestin slightly increases the risk of suffering blood clots, heart attacks and strokes...
...American College of Cardiology in Anaheim, Calif. In a preliminary analysis of a study of 309 women with heart disease, Dr. David Herrington of Wake Forest University School of Medicine in Winston-Salem, N.C., and his colleagues reported that estrogen, taken by itself or in combination with the drug progestin, had no effect for better or worse on the atherosclerotic plaques in the women's coronary arteries. Their conclusion echoes that of another study of female heart patients, published 18 months ago, that showed that estrogen is no better than a placebo at preventing a second heart attack...
...hormone replacement has largely been drawn from studies of the effects of estrogen taken alone, a therapeutic option that is now reserved for women who have undergone hysterectomies. That's because experience has shown that "unopposed estrogen," as doctors call it, elevates the risk of uterine cancer. By adding progestin to the mix, physicians have found, they can protect the uterus from malignant growth. The question Schairer and her colleagues have raised is whether this victory over one form of cancer came at the price of increased risk for another...
...assumed that estrogen and estrogen-progestin were the same," says UCLA breast surgeon Dr. Susan Love, a prominent critic of hormone-replacement therapy. "Suddenly we are starting to get evidence that they're not." Like many others, Love is eagerly awaiting the findings of a large clinical trial launched by the Women's Health Initiative in 1993. That trial, which involves nearly 30,000 women between the ages of 50 and 79, is specifically designed to assess the pros and cons of estrogen-progestin therapy. The first results won't be ready for five more years...