Word: projected
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Dates: during 1980-1989
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...stories strike such emotional resonance among their authors as this week's cover on adoption. The profound complexities of the subject were especially well understood by at least one correspondent, researcher and writer: all three have experienced adoption firsthand. Los Angeles correspondent James Willwerth, who suggested the project, is the adoptive father of Piya, 5, and Mike, 4. Already parents of a son, David, who arrived the conventional way, Willwerth and his wife Ardis chose a daughter and a second son from two different Bangkok orphanages during his assignment in Thailand. Giving a home to "waiting" children "longing for love...
Barnett is one of 51 AIDS patients who, along with six doctors, took part in underground trials of Compound Q this past spring and summer. The clandestine study was organized by Project Inform, a San Francisco-based group of activists who believe the Food and Drug Administration's system for testing potentially life-saving new drugs is unconscionably slow. On Sept. 19, Project Inform director Martin Delaney revealed the preliminary results of the underground trials to an intent crowd of some 500 predominantly gay men in San Francisco. Although many of the trial's volunteers, including Barnett, showed a marked...
...test tubes at least, Compound Q could kill HIV-infected cells while leaving healthy cells unaffected. The substance quickly found its way into the U.S. and to desperate AIDS patients, who administered the drug on their own. "Word was out," says Dr. Alan Levin, medical director of the Project Inform trials in San Francisco. "People started getting it and injecting themselves in their kitchens...
Delaney then asked a group of doctors to design a protocol, or test model, based on an FDA trial for a similar drug called Ricin Toxin. Delaney says several FDA and National Institutes of Health officials in Washington were told of Project Inform's proposed trial, which was planned for patients in San Francisco, Los Angeles and New York City. "At no time did anyone tell us to stop," he says. An FDA spokesman in Washington claims officials did not hear about the clandestine trials until well after they began...
Without revealing the purpose, Project Inform asked Genelabs, Inc., a California biotechnology firm that manufactures the drug in the U.S., to test samples of Compound Q that Corti brought back from China. They wanted to make sure it was identical to the Compound Q used in the FDA-approved study. An attorney drew up guidelines that would keep the trials within federal law. Each patient made a videotaped statement, in the presence of an attorney and a witness, that he was entering the trial of his own free will. "What we wanted was a trial that was faster than...