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...while these hormones have been successfully manipulated in lab mice to prompt weight gain or loss, the same has not been true in humans. Experiments in which obese human patients were injected with leptin have failed, because the metabolic pathways that control hunger and fullness in people are far more complex than they are in mice. Knocking out one of, say, 50 such pathways through drug treatment just means the other 49 will eventually pick up the slack, says Dr. George Fielding, a bariatric surgeon at the NYU Program for Surgical Weight Loss...

Author: /time Magazine | Title: Midnight Snacks: More Fattening Than You Feared? | 9/5/2009 | See Source »

...economic siege. While Hamas is currently enforcing the cease-fire it adopted seven months ago at the close of Israel's Gaza invasion, the economic siege remains largely in place - although if Egyptian-mediated negotiations over the fate of captive Israeli soldier Gilad Shalit are successfully resolved, that might prompt Israel to ease the pressure...

Author: /time Magazine | Title: Behind Hamas' Own War on Terror | 8/21/2009 | See Source »

...crash. In 2008, Australian Broadcasting Corporation's Foreign Correspondent program revealed that 19 of most recent plane crashes in PNG, in which a total of 16 people were killed, none had been properly investigated. Sadly, it looks like it has take the deaths of another 14 people to prompt a proper inquiry into aviation safety in the country...

Author: /time Magazine | Title: Australia Mourns Its Plane-Crash Victims | 8/14/2009 | See Source »

...These rewarding experiences trigger the release of the neurotransmitter dopamine - the brain's "do it again" signal. Over time, addicts' brains become narrowly focused on drug-related pleasures and hypersensitive to cues associated with them, such as seeing an old drinking pal. Hanging out with that friend would prompt a rise in dopamine levels in the brain's reward system. Researchers think that's where baclofen cuts in: by binding to the GABA-B receptor in the brain, it modulates this system and prevents the release of dopamine in response to cues. That appears to short-circuit cravings...

Author: /time Magazine | Title: Treating Alcohol Addiction: A Pill Instead of Abstinence? | 7/29/2009 | See Source »

Highlight Reel: 1. Texting drivers could prompt a "crash epidemic": Truck drivers were 23.2 times more likely to get into a crash or near crash than drivers who weren't distracted. This correlates to the length of time a texting driver's eyes were off the road - almost five seconds, long enough to cover a football field at highway speeds. Given the increasing popularity of texting - it's grown tenfold in the last three years, by one count - it could swiftly become an enormous peril to road safety...

Author: /time Magazine | Title: Texting Drivers, Tempting Fate | 7/29/2009 | See Source »

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