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...designed to paralyze bone-destroying cells - cells that increase in number as people age. While the body continually destroys and replaces bone tissue throughout life, the destruction eventually begins to overtake the construction, and the result in older age is a patchier, weaker type of bone that is more prone to breaking. While bisphosphonates block the activity of bone-destroying cells, denosumab prevents new ones from forming altogether. The end result is a tipping of the bone balance away from bone destruction and toward bone formation. Early studies in mice at Amgen, the company that developed denosumab, showed that animals...
...haunt, and the neighborhood I grew up in—is the sort of Norman Rockwell-ish enclave that tries to embody the most idealized notion of American family values: The houses are large and traditional, the lawns green and resplendent, and the children blonde and bike-prone. It likes to propagate its image as the most down-to-earth of Dallas’s affluent neighborhoods (especially in comparison to the adjacent “Park Cities,” where social intrigue is king). But don’t be fooled. Many of Dallas’s richest...
...random. According to a new study published in the August 7 issue of Science, vulnerability to extinction runs in families, meaning that some groups of species have a higher likelihood of becoming extinct than others. "It turns out that some branches of the tree of life are more extinction-prone than others," says Kaustuv Roy, a biology professor at the University of California, San Diego. "Those traits aren't just a part of extinctions that human beings cause, but a general feature of extinction itself." (See the world's endangered species...
...another run for Bunning would seriously risk just that. During Bunning's last campaign, he endured repeated questions about his age and mental stability. Always prone to outlandish statements, Bunning made news when he said his opponent Daniel Mongiardo, then a state senator and now a lieutenant governor who is expected to run for the seat in 2010, looked like "one of Saddam Hussein's sons." (In 2006, TIME named Bunning one of America's worst Senators...
...funding for PPD testing, an earlier one did (it was based on a New Jersey law that mandates universal PPD screening), and critics say the new act will naturally lead to greater use of screening if it passes. Opponents of the bill contend that mental-health screens are notoriously prone to giving false positives - research suggests that as few as one-third of women flagged by a PPD screen actually have the condition - and say testing is a gambit by pharmaceutical companies to sell more drugs...