Word: properous
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Dates: during 1950-1959
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...idea of a magazine light enough to be carried economically by airplane was a natural for TIME. We had always worked on the principle that the quality of reporting and editing - not the amount of paper covered by words - is the proper standard of good journalism...
Self-Portrait. Our editors recognized Latin America's proper place in world news well before Air Express began. Because of their awareness, TIME was the second U.S. publication (after the New York Times) to operate permanent news bureaus in South America. Over the years, this network of correspondents has expanded. It has supplied important stories for most sections of the magazine and is responsible, of course, for our regular Hemisphere section. Latin American stories have ranged all the way from the Business section's reports on spreading air routes to the Music section's reviews of compositions...
Like other steroid hormones (e.g., testosterone, androsterone, progesterone), cortisone is a tough chemical customer. Its molecules are built around the steroid nucleus" (TIME, Jan. 29) which has three six-atom carbon rings and one five-atom ring in the proper spatial arrangement. To build such a molecule from scratch was considered so difficult that few chemists ever hoped to accomplish...
Woodward started out with orthoto-luidine, an oily liquid extracted from coal tar, whose molecule has one six-carbon ring and one methyl (CH3) group. Step by step he attached more atoms, carefully choosing his reactions so that the atoms would fall in the proper places. After some 20 laboratory steps, his 22 Ibs. of original raw materials were reduced to 1/28 oz. of a genuine steroid. The compound's molecule has the steroid nucleus with an oxygen atom attached at one end and a carbome-thoxy (C02CH3) group at the other...
Chemist Woodward emphasized the fact that his new substance is not yet cortisone. He must add another oxygen atom in the proper spot, and must exchange his carbomethoxy group for a dihydroxyacetone sidechain. In the process it will also be necessary to alter the double bonds that now join some of the atoms in his steroid (see diagram). But Chemist Woodward's cautious colleagues agree that the toughest part of the job seems to be over...