Word: propranolol
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...encouragement. The National Heart, Lung and Blood Institute announced that it was calling an early halt to a large-scale study because the drug being tested was so successful in reducing deaths in heart attack victims. Says NHLBl's associate director, Dr. William Friedewald: "The regular use of propranolol has the potential for saving at least 6,500 lives in the United States alone each year...
...curtailed study began in 1978 and involved almost 4,000 men and women, ages 30 to 69, who had suffered at least one heart attack. Half were given propranolol daily for two years; the rest, similar to the medicated group in sex, age, smoking habits and general medical condition, received placebos. Treatment was started within five to 21 days of the attack. Though the experiment was scheduled to run until June of next year, researchers cut it short when they discovered there were 26% fewer deaths in patients who had taken the drug for at least one year...
...Honored for clinical research were Pharmacologists Raymond P. Ahlquist of the Medical College of Georgia and Dr. J.W. Black of University College of London. Their work led to the development of the drug propranolol (Inderal), which the Lasker jurors, headed by Heart Surgeon Michael DeBakey, hailed as one of the most important drugs of the century for its role in the treatment of high blood pressure (hypertension) and heart disease, the nation's No. 1 killer...
Drug treatments for hypertension continue to improve. Propranolol, a British-developed drug licensed in the U.S. for use in heart problems other than hypertension, is nonetheless widely and successfully used to control high blood pressure. Other potentially valuable drugs, though widely used in Britain, have not yet been approved by the Food and Drug Administration for use in this country. Reserpine remains an effective antihypertensive despite reports linking it with a slightly increased incidence of breast cancer in some women (TIME...
...rush to surgery, Russek feels, is self-destructive; good medical treatment is now available that can control the causes of angina and the crippling heart attacks that often follow. Russek treated one series of 102 patients suffering from severe angina for six years with a special combination of drugs: propranolol (Inderal), a drug that slows down the heart and reduces its need for oxygen, and long-acting nitrates that dilate the blood vessels and increase blood flow to the heart muscle. Only 1.2% of Russek's coronary patients died each year-about the same mortality rate from heart attacks...