Word: prostaglandin
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Dates: during 1970-1979
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...several years, doctors have suspected a link between aspirin and the prostaglandins, but the findings of the Britons, who conducted their work at London's Institute of Basic Medical Sciences, provide the first persuasive proof. In one series of experiments, Dr. John Vane found that aspirin-like drugs impeded the synthesis of a prostaglandin known to cause fever in cats. In another, Dr. Vane and his colleagues Sergio Ferreira and Salvador Moncada found that aspirin blocked the release of prostaglandins in a dog's spleen that had been removed and kept functioning artificially. In a third, Drs. John...
...result of uncommon-sense reasoning, doctors are inducing early abortions with prostaglandin F2 alpha, a hormone-like substance derived from semen. The prostaglandins are a class of chemicals, 16 of which have now been isolated, that were originally believed to be secreted in the prostate gland. The first were found in human semen, which is still the richest source known. Now prostaglandins are known to occur in many other human tissues and in menstrual fluid. They are also found in the semen of sheep, and it was from the seminal vesicles of rams that medical researchers obtained their early supplies...
...first detailed report of success with PG abortions comes from King's College Hospital in London. There, Obstetrician Gilbert M. Filshie worked with Dr. S.M.M. Karim, a biochemist, to select a prostaglandin that would induce an abortion early in pregnancy, yet produce a minimum of side effects, such as altering the blood pressure. They devised a solution containing 50 micro-grams of PG F2 alpha per milliliter, and infused it into the veins of 15 women who were from nine to 22 weeks pregnant. The amount was tiny: only one milliliter (one-fifth of a teaspoonful) per minute...