Word: proteins
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Currently, most anti-HIV drugs target individual proteins, and are given in combination as a cocktail. However, according to D’Souza, HIV is mutating and building up resistance to the cocktail. By studying the RNA-protein complex, which is crucial to the virus’ survival, D’Souza aims to sophisticate the current approach to AIDS treatment...
...next three to four years, D’Souza says she should be close to solving the structure of the RNA-protein complex, which is, according to her, “probably the most difficult part...
...next step would be to conduct drug-binding experiments. According to D’Souza, an effective drug would target the interaction between RNA and the reverse transcriptase protein, unlike current drugs which target just the protein...
...discovered D’Souza’s lab by “a stroke of luck,” and that he hopes to work there until he graduates. “What really interested me about her research was her novel idea to look at RNA-protein interactions...it’s something that could probably have a higher payoff,” Katz says...
...Nurses’ Health Study, a sweeping project which collected data from over 120,000 women starting in 1976. HSPH researchers also found that there was an association between a lowered risk of heart disease and low-carb diets that were high in vegetable sources of fat and protein. “We are not recommending a low-carb diet over a low-fat diet,” said Thomas L. Halton, one of the authors of the study. “The truth of the matter is that neither [is] ideal. Both have good points and bad points...