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Nose drops developed by Harvard Medical School researchers have impeded the development of Alzheimer’s disease in mice, and an anti-Alzheimer’s nasal spray for humans could be on the horizon. While plaques made up of beta-amyloid proteins accumulate in the brains of Alzheimer’s sufferers, the new vaccine allows the immune system to produce antibodies that fight these proteins. In tests that have are detailed in the latest issue of the Journal of Neuroscience, the vaccine significantly diminished plaques on the brains of treated mice. Similar tests on human subjects began...

Author: By Kevin C. Reyes, CONTRIBUTING WRITER | Title: HMS Seeks Alzheimer’s Vaccine | 5/5/2006 | See Source »

...licensed the patent by Harvard, MIT, and the Whitehead Institute for Biomedical Research, the other plaintiffs in the case. In the 1980s, scientists from those institutions discovered a method of treating diseases by regulating the activity of a molecule called NF-kB—a transcription factor involved in protein production. When the discovery was eventually awarded a patent in 2002, Ariad and the three institutions sued Eli Lilly in the U.S. District Court for the District of Massachusetts. Evista helps prevent and treat osteoperosis and Xigris treats people with severe sepsis. Royalties from that patent could be a windfall...

Author: By Nicholas M. Ciarelli, CRIMSON STAFF WRITER | Title: Jury Rules Company Infringed Drug Patent | 5/5/2006 | See Source »

...trial began April 10 in U.S. District Court for the District of Massachusetts. Closing arguments are scheduled to take place tomorrow. The patent covers methods of treating diseases by modulating the activity of the molecule NF-kB, a “transcription factor” involved in protein production. Scientists from Harvard, MIT, and the Whitehead Institute discovered these methods in the 1980s, and the institutions licensed the patent exclusively to Cambridge-based Ariad. The four parties filed suit against Eli Lilly on the same day the patent was awarded, according to Laurie A. Allen, senior vice president for legal...

Author: By Nicholas M. Ciarelli, CRIMSON STAFF WRITER | Title: Patent Dispute Winds Down | 4/27/2006 | See Source »

...master regulatory genes deactivated. ES cells have the potential to become any other type of tissue cell, but how they do so is not clear and is essential if treatments are to be developed from research. This process of activating master regulatory genes is facilitated by chromatin, a histone protein structure that contains a cell’s DNA. If there is a methyl group anchored in a certain place on one histone protein, the gene nearby is activated (known as the K4 state). Conversely, if the methyl group attaches itself to another part of the protein, the gene...

Author: By Shaunak A. Vankudre, CONTRIBUTING WRITER | Title: Researchers Make Stem Cell Find | 4/24/2006 | See Source »

...challenge is to find a way to identify and isolate those cells. Scientists are starting with what they know, analyzing the proteins that stud the surface of normal stem cells and looking for proteins unique to the cancerous cells. So far, leukemia experts have the edge, working from the knowledge of blood stem cells they have been building since the 1940s. Dick's group in Toronto was the first to identify a protein, CD34, as a potential screen for leukemia stem cells. He showed that tumor cells with plenty of CD34, when injected into mice, flowered into cancerous growths. Leukemia...

Author: /time Magazine | Title: Stem Cells That Kill | 4/17/2006 | See Source »

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