Word: provera
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...advocates argue that it is the best available method of birth control: not only is the drug nearly 100% effective, but it has to be taken just four times a year. Depo-Provera has been used by 10 million women over the past 15 years in more than 80 nations, including some in Western Europe. It has been approved by the World Health Organization, the American College of Obstetrics and Gynecology and the International Planned Parenthood Federation, which has widely distributed the drug in Third World countries. Despite its popularity overseas, however, Depo-Provera is not approved as a contraceptive...
Like the birth-control pill, Depo-Provera works by disrupting the female hormonal cycle that normally leads to ovulation. The drug, which is injected, is a synthetic version of the hormone progesterone, similar to one of the two main ingredients of the birth-control pill. It does not, however, contain estrogen, and therefore does not seem to share the most serious drawbacks of the Pill: increased risk of abnormal blood clots and heart attacks. Depo-Provera can have less serious side effects that persist as long as it is in the bloodstream. Among them: weight gain, loss of sex drive...
Upjohn has been haunted, however, by its own early tests of Depo-Provera in animals. In a seven-year, controlled study using beagles, two out of 16 dogs developed breast cancer. Results from a ten-year study using 52 rhesus monkeys were equally alarming: two of the animals developed cancer of the endometrium (the lining of the uterus). Upjohn's own scientists concluded in 1978 that the cancer was "likely related to treatment with Depo-Provera." Later that year the FDA refused to allow Upjohn to market the drug as a contraceptive, though it is approved for treating certain...
Since then, Upjohn has challenged the validity of its own tests. According to company scientists and a number of outside experts, both beagles and rhesus monkeys are highly sensitive to progesterone and are more likely than humans to develop cancer in response to it. Depo-Provera partisans further claim that there has been no increase in the rate of cancer among women taking the drug in countries where it is approved. Says Gynecologist Elizabeth Connell of Atlanta's Emory University: "It appears to be as safe or perhaps safer than oral contraceptives or intrauterine devices...
...born without a right hand. She has a sister named Minnie, 14, and as they grew old enough to attract boys, welfare workers steered them to a federally financed family planning center in Montgomery, Ala., where they received injections every three months of a drug called Depo-Provera, which was being tested as a contraceptive...