Word: pump
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Dates: during 1990-1999
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Since 1977, scientists have sought a substance which experimental evidence had demonstrated prevents the proper functioning of the sodium-potassium pump, a cell regulatory mechanism which helps to maintain a proper balance of ions in the cell...
Haupert, who describes the possibilities of future HIF research as "tempting," hopes that the research will help scientists better understand HIF's effects on the pump and, in turn, to refine existing drugs which combat high blood pressure. For example, one such drug might be comprised of chemicals which block the actions...
...only known cell pump regulator at that time was digitalis, a plant substance currently used as a drug to treat heart conditions. But Haupert says he questioned the idea that only once substance exists to control such an integral aspect of homeostasis...
...should we as mammals have a pump of so much importance whose only regulator is...from the plant kingdom?" he queried...
Haupert and scientists at the MGH reasoned that an analogous substance could be present in mammalian cells, and began in 1977 to target organs in which the pump plays a key role...