Word: puromycin
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...does not store memories; instead, it may play an intermediary role, stimulating the brain to produce proteins that are perhaps the actual repositories of memory. In one experiment inspired by that theory, University of Michigan Biochemist Bernard Agranoff taught goldfish to swim over a barrier, then injected them with puromycin, an antibiotic that prevents protein synthesis. When the injection was given hours after learning, it had no effect, suggesting that memory proteins had already formed. Injected just before or just after training, the drug prevented learning...
...when injected into untrained animals. Converse evidence that chemicals are involved in forgetting came from the University of Michigan's Dr. Bernard W. Agranoff, who reported that trained goldfish forgot how to avoid a shock, and untrained fish did not learn as well after injections of the antibiotic puromycin...
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