Word: pyridon
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Dates: during 1930-1939
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...State Hospital at Altona, later under Professor Alexander von Lichtenberg at St. Hedwig Hospital, Berlin. To Altona, Professor Arthur H. Binz, organic chemist, sent an iodine compound which he wanted Professor Lichtwitz to use on cows infected with streptococci. The compound was N-methyl-5-iodo-z-pyridon. Dr. Swick, inquisitive, knew about all the scientific work going on at Altona. With a retentive memory, he knew that Dr. Leonard George Rowntree of the Mayo Clinic in 1923 had illuminated the kidneys & ureters faintly with sodium iodide. The iodine created the opacity. Dr. Swick asked permission to try the Binz...
Whenever vision is suddenly affected by a drug there probably is a methyl radical (CH3) involved. Professor Binz's compound had such a methyl radical. Not worried, he offered to synthesize a more tolerable iodine preparation, soon furnished 5-iodo-2-pyridon-N-acetate of sodium, which he calls Uroselectan and U. S. urologists lopax. Injected in the veins it rapidly collects in the kidneys and shows by means of x-rays the shape of those organs and any stones or malformations there or in the ureters (leading from the kidneys to the bladder...
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