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Reporting this week in the Archives of General Psychiatry, scientists describe for the first time a set of genes, about 100 in all, that seem to predict how well a smoker will respond to two different types of quitting programs - nicotine replacement or bupropion (Zyban). Nicotine-replacement methods, including the patch, pill and gum, work by weaning the smoker off nicotine gradually, usually over a period of weeks or months. Bupropion, on the other hand, is an antidepressant, which does not contain nicotine; instead, it works to curb nicotine cravings by interfering with the reward circuit in the brain, where...
...boost the quitting success rate would be to match smokers with the right cessation program. A team of researchers, led by Jed Rose, director of the Duke University Center for Nicotine and Smoking Cessation Research, have begun doing just that. In their new study, the scientists screened the entire human genome and teased out a profile of genes that they think are involved in breaking nicotine addiction. Some of the genes influence basic cell communication; others code for enzymes that break down bupropion in the body. Everyone possesses all the genes in question, says Rose, but in different forms...
...Whores is Pisani's story of more than a decade spent working in HIV prevention. She starts with her decision in 1994 to give up journalism and study epidemiology - "Sex, drugs and plenty of squeamish politicians. AIDS was the disease for me," she writes - and ends after she quit her job in 2005, following a meeting of epidemiologists in Bangkok that left her doubting the impact of science on real-world AIDS policy. Along the way, Pisani draws on anecdotes from her time chatting with transvestite hookers, rich-kid junkies, epidemiologists and policymakers in Indonesia, where she spent...
Your character on Rescue Me quit smoking. Were you actually trying to quit yourself? Barbara Bean, DORCHESTER, MASS...
...Westminster palace coup is by no means an easy feat, nor a likely one. Complex Labour Party rules and regulations specify that a leadership contest can only happen if the Prime Minister quits or is challenged. There is no indication that Brown is ready to quit. A successful challenger would need the backing of 20% of Labour MPs (at least 71 on current standings). That is a hard number to attain even in the current climate. And even if a challenger emerged, it would fall to the Labour Party Conference in the autumn to decide, by a public vote...