Word: ra
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Most of these drugs are genetically engineered biological molecules, and the majority are designed to treat rheumatoid arthritis and its close clinical relative, lupus. Like many other autoimmune diseases, both disorders strike women disproportionately. In RA, the immune system attacks the joints and eventually weakens the bones, causing excruciating pain, fatigue and daily bouts of fever. With lupus, the attack is far more generalized, affecting blood vessels, joints, skin and several internal organs. In severe cases, it can be lethal...
That story, in fact, has inspired trials of nearly two dozen new biotech medicines. IDEC Pharmaceuticals in San Diego, for example, has zeroed in on the interactions between CD4 T cells and APCS to make antibody drugs against lupus and RA. The company's anti-RA antibody selectively switches off T cells involved in autoimmune responses by binding the CD4 molecule on their surfaces. Amgen, of Thousand Oaks, Calif., has a drug that blocks Interleukin-1, another molecule that promotes inflammation...
...Many alumnae have been saddened by the fact that they no longer have a school," said President of the Radcliffe Association (RA) A'Lelia P. Bundles '74. "But that's a reality we can't change. If Dean Faust follows through on her plans to make the Institue a compelling, interesting and engaging place, I think she'll engender the affection of Radcliffe women...
Judith Stanton, executive director of the RA, said that Radcliffe has recently started to send speakers to Harvard Clubs across the country in an effort to include both male and female alumni in Radcliffe activities...
Thanks to technologies spawned by genomics, the list of potential drug targets is growing rapidly. Human Genome Sciences and Seattle-based ZymoGenetics, for instance, are independently developing drugs to inhibit a newly discovered factor that stimulates B cells and is produced copiously in RA and lupus patients...