Word: rare
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Dates: during 1980-1989
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Congress tries to encourage new remedies for rare diseases...
Dobkin is one of millions of Americans who suffer from diseases so rare there is no profit in making drugs to treat them. A pharmaceutical company's investment, up to $80 million for a new drug, cannot be recouped if only 100,000 people or fewer need the product. Such diseases and their drug treatments therefore are said to be "orphaned." Orphan diseases include cystic fibrosis, a deadly hereditary disorder that affects 40,000 Americans; Tourette's syndrome, a neurological abnormality characterized by tics and involuntary outbursts of swearing (100,000 Americans); Prader-Willi syndrome, a children...
...provision in the original bill that would have permitted approval of orphan drugs after one successful human clinical trial. With that provision dropped and other changes made, the P.M.A. now supports the bill, though it continues to defend its past record in producing orphan drugs. Some 40 drugs for rare diseases have been marketed since 1970, says Dr. George Goldstein of the P.M.A. He adds: "Industry has acted and will continue to act responsibly...
...enthusiasm led him astray. An early version of Island Fling "really wasn 't good enough and was curiously overwritten," he decides. "I seem, in later years, to have lost my gift for economy. This has been, and in the future must continue to be, remedied." It is a rare writer who is his own best critic...
...meeting by withdrawing from the room. On rare occasions, it resulted in Begin's changing his mind. This was one of those times...