Word: ravens
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Dates: during 2000-2009
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...that will make you want to open a vein. The sheer volume and relentlessness of Oberst's agony (at 24, he has made nine albums fronting four bands--most famously Bright Eyes, a rotating group of musically inclined depressives), combined with his puppy-dog gaze and lock of drooping-raven hair, give him an inescapable aura of adolescent wallowing. He looks the way a My So-Called Life script sounds...
Genentech says it pioneered the use of antibodies that target the surface protein of cancer, and its popular drugs work on that principle. Nevertheless, Mather saw a way to carve several years out of drug development and left to found Raven Biotechnologies, a drug-discovery company based in South San Francisco. She created a process to keep cells alive outside the body, so she could test her theory in the lab. Her efforts paid off. In December the U.S. Food and Drug Administration approved one of her drugs for human testing. The drug, called RAV 12, is a protein that...
...Margot Theis Raven; Pictures by E.B. Lewis...
...business leaders best known for its annual meeting in Davos, Switzerland. Selected from among 114 nominees by a panel of technology experts, the Pioneers' biotech developments augur advances that will help people live longer, healthier, more productive lives. Pioneers like Arryx; Astex, a biotech firm in Cambridge, England; Raven Biotechnologies and Xencor, both in California; and Memory Pharmaceuticals of Montvale, New Jersey, are targeting cancer, Alzheimer's, nutrition, animal husbandry - you name it. Their innovations are a testimony to the do-it-yourself spirit that fuels both technology and entrepreneurship. Indeed, many of this year's Pioneers had to leave...
...Another disease-fighting Pioneer is Jennie Mather of Raven Biotechnologies in South San Francisco. Like Jhoti, Mather is out to fight cancer, but her approach is radically different. She postulated that what really counts in a target protein - that is, a protein that causes a disease and that a drug would aim to disable - is the protein's surface. Since a body's natural antibodies never enter a diseased cell but do their work entirely on the cell's exterior, she reasoned, drugs should work the same way. Such thinking was heresy to her former employer Genentech, which analyzes...