Word: receptor
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Herceptin is only a beginning, says UCLA's Slamon, who identified the HER2 receptor. There are bound to be other cancer proteins that pharmaceutical manufacturers can use as targets as they develop new, more selective drugs. "Using a combination of [these kinds of] therapies earlier in the disease could have a dramatic impact on outcomes," Slamon says...
Ideally, Singletary would like to be able to tailor each woman's treatment to the characteristics of her particular tumor. Already scientists have identified a biological marker called the HER2 receptor, whose presence usually signifies a very aggressive cancer. For the past four years, a drug called Herceptin has been given to women with metastatic tumors that make a lot of the HER2 protein. Now trials are being conducted to see if Herceptin, which may have some deleterious effects on the heart, will nonetheless help other women with smaller tumors that haven't yet spread...
...chemical factors that control the circadian rhythms work through a receptor known as TGF alpha that then communicates with the nerve cells. The factors regulate daily physical activity, as well as the sleep-wake cycle...
...circadian factors found by the HMS researchers were identified in a hamster. The findings are strengthened by a separate study that shows that mice with deficient quantities of the receptor do not have normal circadian patterns...
...three women are well advanced in research. Robertson, who began her research in 1975, studies autonomic cardiovascular control. Donahoe investigates congenital anomalies in children and their causes. Young conducts brain receptor research in relation to neurodegenerative diseases, and was part of the team of scientists who discovered the gene for Huntington’s disease...