Word: receptor
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...this be used to help autistic kids? Nobody recommends inducing fevers to kick-start the locus coeruleus, since that could lead to all manner of side effects and other ills. Instead, Mehler and Purpura believe the likeliest answer is in medications that target noradrenaline brain receptors. "First, we should look at the signaling pathways in the region of the brain involved," Purpura says. "Then we could look at treating the receptor sites with some kind of pharmacotherapy." For once, the step that's missing from a proposal is the one that involves shouting about what's to blame...
...vision and he will be extraordinary.” Engleman said. He said that Lynch, along with Cancer Center Director Daniel A. Haber, led what was probably the biggest discovery in lung cancer in the last 20 years. Lynch helped identify a new kind of mutation in the EGF receptor that has led to treatment for patients with this genetic mutation. “Because of this work we now routinely do this genetic test on our patients, and if they have this mutation, they take a pill once a day and have a great chance of achieving remission...
...those thrill seekers differed in any way from those of the less adventuresome when it comes to dopamine. He gave 34 men and women a questionnaire to assess their novelty-seeking tendencies, then scanned their brains using a technique called positron emission tomography to figure out how many dopamine receptors the participants had. Zald and his team were on the lookout for a particular dopamine-regulating receptor, which monitors levels of the neurotransmitter and signals brain cells to stop churning it out when there's enough...
...Kahn began studying diabetes in 1970, when he started a fellowship at the NIH’s National Institute of Diabetes and Digestive and Kidney Disease (NIDDK). When Kahn began his research, it was known that insulin regulated blood sugar by binding to a specific receptor on cells. But Kahn’s lab was the first to discover the mechanism of this activation, which involves the addition of a phosphate molecule to the amino acid tyrosine...
...Steven J. Russell says he was attracted to Joslin by Kahn’s reputation as a mentor, and by his work with the recently developed fat-specific insulin receptor knockout mouse, a genetically modified animal whose fat cells are unaffected by insulin. The lean, long-lived mouse holds potential for treating diabetes and aging in general, and it is only one of the many topics studied in Kahn’s interdisciplinary, collaborative...