Word: receptors
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According to a press release from ICN, Harrison was the first scientist to determine the three-dimensional structure of a virus. He ushered in an era where the details of virus-cell interactions can be studied at the atomic level. He also analyzed the receptor for HIV and proposed rules of protein-protein interactions...
...alarmed at the monster that Johns Hopkins neuroscientist Solomon Snyder and I created when we discovered the simple binding assay for drug receptors 25 years ago. Prozac and other antidepressant serotonin-receptor-active compounds may also cause cardiovascular problems in some susceptible people after long-term use, which has become common practice despite the lack of safety studies...
GABA, which binds to the GABAc receptor, is a major inhibitory substance in the brain. If GABA is impaired, the result is an over excitation of retinal cells, which could result in glaucoma...
...effects vary widely, however, depending on a variety of factors. To begin with, each neurotransmitter can latch onto more than one kind of receptor. As many as 15 distinct receptors have been identified for serotonin alone. And since a given nerve cell may have more or fewer receptors, depending on where in the brain it is located, a jolt of a particular neurotransmitter can generate electrical signals of widely varying strengths. Small wonder, therefore, that serotonin can affect everything from satiety to depression...
...therapy. A number of well-tolerated MAO B-inhibitor drugs developed to treat Parkinson's disease could find a place in the antismoking arsenal. Equally promising, a Yale University team led by Eric Nestler and David Self has found that another type of compound--one that targets the dopamine receptor known as D1--seems to alleviate, at least in rats, the intense craving that accompanies withdrawal from cocaine. One day, suggests Self, a D1 skin patch might help cocaine abusers kick their habit, just as the nicotine patch attenuates the desire to smoke...