Word: reichstein
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Dates: during 1950-1959
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Meanwhile, before last week's sessions broke up, the experts got news of yet another potential medical tool. Nobel Prizewinner Tadeus Reichstein of Basel University announced that he had isolated a powerful adrenal hormone which he provisionally called "electrocortin." Since the newly isolated hormone undoubtedly plays a part in the body's balances. Dr. Hench called electrocortin "the biggest thing" of the congress, but neither he nor Dr. Reichstein would prophesy as to its therapeutic possibilities. Whatever its potentialities in the treatment of arthritis and other diseases, electrocortin will probably not be available in large quantities for some...
Fourteen more steps in processes worked out by Tadeus Reichstein, a Swiss chemist, and Lewis H. Sarett of Merck & Co. lead to cortisone itself...
Last week Syntex announced that a group of its chemists headed by Dr. George Rosenkranz had at last accomplished the feat, starting with diosgenin from cabeza de negro. They transformed it by 18 chemical steps to "Reichstein's Compound D,* which had been found in minute quantities in the adrenal gland, but had never been synthesized. Only three more steps were needed to turn this compound into cortisone...
Last week, for their work with cortisone and other adrenal hormones, Drs. Edward Calvin Kendall, Philip Showalter Hench and Tadeus Reichstein were awarded the 1950 Nobel Prize for medicine. In the three-way split, each will...
Years passed, during which this hormone had little practical value. Meanwhile, Reichstein ran the number of hormones and similar substances found in the adrenal glands to 28, and Kendall kept trying to synthesize compound E, or something like it. At last Kendall and others succeeded, and late in 1948, a colleague at the Mayo Clinic, Dr. Philip Hench, directed the first injections of cortisone to human victims of rheumatoid arthritis. The results were dramatic. Suddenly, a vast new field of medical research was opened...