Word: repressor
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Dates: during 1990-1999
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...fellow at Harvard, Ptashne rose to fame after isolating the repressor of lambda phage virus. The lambda virus is able to remain dormant in E. coli bacteria because its repressor binds to the viral DNA, preventing the expression of the genes necessary for viral replication...
...repressor motif is used in gene regulation in many other organisms, but for years, prominent researchers had failed to isolate a repressor, Ptashne says...
...went into science because I became alerted to the idea of there being a repressor and began collaborating and competing with [Leob University Professor] Wally Gilbert, who was at the time looking for the lac repressor," Ptashne says...
Ptashne recorded his work with lambda repressor in 'A Genetic Switch,' a monograph considered by many scientists to be one of the classics of molecular biology. The book is used by Harvard students taking Biological Sciences 10: "Introductory Molecular Biology," Biological Sciences 14: "Genetics," and Biological Sciences 1: "Introductory Genetics, Molecular, Cellular and Developmental Biology...
...focus is proving it is a repressor, and to understand what the gene has to do with control of the white blood cell," he said. "We hope to use the white blood cell as s model system and also to use it to understand what [CDP] does in early development...