Word: repressor
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According to a news release from the Albert and Mary Lasker Foundation, Ptashne "pioneered the molecular basis of gene regulation and isolated the molecule called a 'lambda repressor' which functions as a switch turning gene expression...
...went into science because I became alerted to the idea of there being a repressor and began collaborating and competing with [Leob University Professor] Wally Gilbert, who was at the time looking for the lac repressor," Ptashne says...
Ptashne recorded his work with lambda repressor in 'A Genetic Switch,' a monograph considered by many scientists to be one of the classics of molecular biology. The book is used by Harvard students taking Biological Sciences 10: "Introductory Molecular Biology," Biological Sciences 14: "Genetics," and Biological Sciences 1: "Introductory Genetics, Molecular, Cellular and Developmental Biology...
After characterizing the lambda repressor, Ptashne began applying the principles of gene regulation in lambda phage virus to higher organisms...
Ptashne says he hopes an understanding of the basic mechanism of the repressor's activity can be applied to broader issues, such as determining the evolutionary basis of transcription-based gene regulation...